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In addition, other studies have shown that CoQ 10 H 2 content in adipose tissue gradually decreased with the development of obesity in both mice and humans, and that CoQ 10 H 2 synthesis-related enzymes were upregulated as a compensatory measure 43

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Loss of ABHD15 impairs the anti-lipolytic action of insulin by altering PDE3B stability and contributes to insulin resistance

Neurosci Lett 13(2):209212 Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME (2002) CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events